Gene therapy in the putamen for curing AADC deficiency and Parkinson's disease
Abstract
This commentary provides an overview of the putamen as an established target site for gene therapy in treating aromatic l-amino acid decarboxylase (AADC) deficiency and Parkinson's disease, two debilitating neurological disorders that involve motor dysfunction caused by dopamine deficiencies. The neuroanatomy and the function of the putamen in motor control provide good rationales for targeting this brain structure. Additionally, the efficacy...
Paper Details
Title
Gene therapy in the putamen for curing AADC deficiency and Parkinson's disease
Published Date
Aug 23, 2021
Journal
Volume
13
Issue
9
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