Aberrant Epigenetic Alteration of PAX1 Expression Contributes to Parathyroid Tumorigenesis

Volume: 107, Issue: 2, Pages: e783 - e792
Published: Aug 28, 2021
Abstract
Primary hyperparathyroidism (PHPT) results from the hypersecretion of parathyroid hormone from parathyroid tumors. A transcription factor, namely Paired box1 (PAX1), is active in parathyroid gland development.We aimed to study potential epigenetic-mediated mechanism of PAX1 gene in sporadic parathyroid adenomas.In parathyroid adenomas tissues, we analyzed the DNA methylation via bisulfite-specific polymerase chain reaction (BSP) and histone...
Paper Details
Title
Aberrant Epigenetic Alteration of PAX1 Expression Contributes to Parathyroid Tumorigenesis
Published Date
Aug 28, 2021
Volume
107
Issue
2
Pages
e783 - e792
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