Long-circulating XTEN864-annexin A5 fusion protein for phosphatidylserine-related therapeutic applications
Abstract
Annexin A5 (anxA5) is a marker for apoptosis, but has also therapeutic potential in cardiovascular diseases, cancer, and, due to apoptotic mimicry, against dangerous viruses, which is limited by the short blood circulation. An 864-amino-acid XTEN polypeptide was fused to anxA5. XTEN864-anxA5 was expressed in Escherichia coli and purified using XTEN as tag. XTEN864-anxA5 was coupled with DTPA and indium-111. After intravenous or subcutaneous...
Paper Details
Title
Long-circulating XTEN864-annexin A5 fusion protein for phosphatidylserine-related therapeutic applications
Published Date
Aug 17, 2021
Journal
Volume
26
Issue
9-10
Pages
534 - 547
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