Spontaneous Regression of Unilateral Conjunctival Primary Acquired Melanosis

An 85-year-old healthy White woman was assessed for extensive primary acquired melanosis involving the left bulbar conjunctiva (Fig A, B). She had no history of autoimmune disease or previous cutaneous melanoma. Her right eye showed no abnormalities. As the pigmentation had been present for at least 50 years, we opted to closely observe the patient, without any treatment. During the next 5 years, the area of pigmentation progressively decreased...