Can extracellular vesicles produced during infection by Trypanosoma cruzi function as damage-associated molecular patterns in the host?

Blood pathogenic trypanosomatids as Trypanosoma cruzi, the causative agent of Chagas Disease, have specialized systems to export virulence factors into host cells. Extracellular vesicles shed by T. cruzi promote infection susceptibility of host cells. Sterile inflammation is part of the innate immune response to molecules released upon tissue injury and is collectively indicated as damage-associated molecular patterns. The complex regulatory...