Empagliflozin and Major Renal Outcomes in Heart Failure.

Published on Aug 27, 2021in The New England Journal of Medicine74.699
· DOI :10.1056/NEJMC2112411
Milton Packer120
Estimated H-index: 120
(Baylor University Medical Center),
Javed Butler99
Estimated H-index: 99
(University of Mississippi)
+ 8 AuthorsChristoph Wanner19
Estimated H-index: 19
(University of Würzburg)
Empagliflozin and Renal Outcomes in Heart Failure In a planned pooled analysis of two trials that evaluated empagliflozin in patients with heart failure, major adverse renal outcomes occurred in 2....
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Sodium-glucose cotransporter type 2 inhibitors (SGLT2is) are new oral glucose-lowering agents that provide cardiovascular and renal protection in both patients with and without type 2 diabetes. Because of their unique mechanism of action, increased glucosuria is associated with osmotic diuresis and some natriuresis, yet the latter seems mostly transient. The potential role of the diuretic effect in overall cardiovascular and renal protection by SGLT2is remains a matter of debate. Precise evaluat...
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