MCU overexpression evokes disparate dose-dependent effects on mito-ROS and spontaneous Ca2+ release in hypertrophic rat cardiomyocytes
Volume: 321, Issue: 4, Pages: H615 - H632
Published: Oct 1, 2021
Abstract
Defective intracellular Ca 2+ homeostasis and aberrant mitochondrial function are common features in cardiac disease. Here, we directly compared potential benefits of mito-ROS scavenging and restoration of mito-Ca 2+ uptake by overexpressing MCU in ventricular myocytes from hypertrophic rat hearts. Experiments using novel mito-ROS and Ca 2+ biosensors demonstrated that mito-ROS scavenging rescued both cytosolic and mito-Ca 2+ homeostasis,...
Paper Details
Title
MCU overexpression evokes disparate dose-dependent effects on mito-ROS and spontaneous Ca2+ release in hypertrophic rat cardiomyocytes
Published Date
Oct 1, 2021
Volume
321
Issue
4
Pages
H615 - H632
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