POLE, POLD1, and NTHL1: the last but not the least hereditary cancer-predisposing genes
Abstract
POLE, POLD1, and NTHL1 are involved in DNA replication and have recently been recognized as hereditary cancer-predisposing genes, because their alterations are associated with colorectal cancer and other tumors. POLE/POLD1-associated syndrome shows an autosomal dominant inheritance, whereas NTHL1-associated syndrome follows an autosomal recessive pattern. Although the prevalence of germline monoallelic POLE/POLD1 and biallelic NTHL1 pathogenic...
Paper Details
Title
POLE, POLD1, and NTHL1: the last but not the least hereditary cancer-predisposing genes
Published Date
Aug 6, 2021
Journal
Volume
40
Issue
40
Pages
5893 - 5901
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