Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions

Published on Aug 9, 2021in Journal of Radiation Research2.724
· DOI :10.1093/JRR/RRAB069
Takahiro Kataoka16
Estimated H-index: 16
(RMIT: RMIT University),
Hina Shuto1
Estimated H-index: 1
(RMIT: RMIT University)
+ 8 AuthorsHiroaki Terato1
Estimated H-index: 1
(Okayama University)
Sources
Abstract
Radon inhalation decreases the level of lipid peroxide (LPO); this is attributed to the activation of antioxidative functions. This activation contributes to the beneficial effects of radon therapy, but there are no studies on the risks of radon therapy, such as DNA damage. We evaluated the effect of radon inhalation on DNA damage caused by oxidative stress and explored the underlying mechanisms. Mice were exposed to radon inhalation at concentrations of 2 or 20 kBq/m3 (for one, three, or 10 days). The 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels decreased in the brains of mice that inhaled 20 kBq/m3 radon for three days and in the kidneys of mice that inhaled 2 or 20 kBq/m3 radon for one, three or 10 days. The 8-OHdG levels in the small intestine decreased by approximately 20-40% (2 kBq/m3 for three days or 20 kBq/m3 for one, three or 10 days), but there were no significant differences in the 8-OHdG levels between mice that inhaled a sham treatment and those that inhaled radon. There was no significant change in the levels of 8-oxoguanine DNA glycosylase, which plays an important role in DNA repair. However, the level of Mn-superoxide dismutase (SOD) increased by 15-60% and 15-45% in the small intestine and kidney, respectively, following radon inhalation. These results suggest that Mn-SOD probably plays an important role in the inhibition of oxidative DNA damage.
📖 Papers frequently viewed together
References30
Newest
#1Takahiro Kataoka (RMIT: RMIT University)H-Index: 16
#2Norie Kanzaki (JAEA: Japan Atomic Energy Agency)H-Index: 4
Last. Kiyonori Yamaoka (RMIT: RMIT University)H-Index: 28
view all 11 authors...
Radon inhalation activates antioxidative functions in mouse organs, thereby contributing to inhibition of oxidative stress-induced damage. However, the specific redox state of each organ after radon inhalation has not been reported. Therefore, in this study, we evaluated the redox state of various organs in mice following radon inhalation at concentrations of 2 or 20 kBq/m3 for 1, 3 or 10 days. Scatter plots were used to evaluate the relationship between antioxidative function and oxidative stre...
Source
Largely unnoticed, all life on earth is constantly exposed to low levels of ionizing radiation. Radon, an imperceptible natural occurring radioactive noble gas, contributes as the largest single fraction to radiation exposure from natural sources. For that reason, radon represents a major issue for radiation protection. Nevertheless, radon is also applied for the therapy of inflammatory and degenerative diseases in galleries and spas to many thousand patients a year. In either case, chronic envi...
Source
#1Werner Hofmann (University of Salzburg)H-Index: 37
#2Wei Bo LiH-Index: 4
Last. Imre BalásházyH-Index: 20
view all 7 authors...
At the tissue level, energy deposition in cells is determined by the microdistribution of alpha-emitting radionuclides in relation to sensitive target cells. Furthermore, the highly localized energy deposition of alpha particle tracks and the limited range of alpha particles in tissue produce a highly inhomogeneous energy deposition in traversed cell nuclei. Thus, energy deposition in cell nuclei in a given tissue is characterized by the probability of alpha particle hits and, in the case of a h...
Source
#1Miriam Kullmann (FAU: University of Erlangen-Nuremberg)H-Index: 1
#2Paul F. Rühle (FAU: University of Erlangen-Nuremberg)H-Index: 8
Last. Benjamin Frey (FAU: University of Erlangen-Nuremberg)H-Index: 53
view all 11 authors...
Sustained pain relief following radon spa therapy in patients suffering from chronic painful diseases has been well described. But still, the underlying mechanisms are not fully understood. We conducted the prospective and explorative RAD-ON01 study which included 103 patients who suffered from chronic painful musculoskeletal disorders of the spine and/or joints and present here the data of the examination of pro- and anti-inflammatory cytokines in the serum of the patients before and at weeks 6...
Source
#1Gao Yanxiao (CCDC: Chinese Center for Disease Control and Prevention)H-Index: 1
#2Tian Mei (CCDC: Chinese Center for Disease Control and Prevention)H-Index: 2
Last. Liu Jianxiang (CCDC: Chinese Center for Disease Control and Prevention)H-Index: 2
view all 5 authors...
This study explored the effects of long-term bathing in radon hot springs on oxidative damage and antioxidation function in humans. In this study, blood was collected from residents in the Pingshan...
Source
#1Krithika Lingappan (BCM: Baylor College of Medicine)H-Index: 17
Abstract The transcription factor nuclear factor-κB (NF-κB) modulates gene expression in diverse cellular processes such as innate immune response, embryogenesis and organ development, cell proliferation and apoptosis, and stress responses to a variety of noxious stimuli. When cellular production of reactive oxygen species (ROS) overwhelms its antioxidant capacity, it leads to a state of oxidative stress, which in turn contributes to the pathogenesis of several human diseases. Different models o...
Source
#1Takahiro Kataoka (RMIT: RMIT University)H-Index: 16
#2Reo Etani (RMIT: RMIT University)H-Index: 5
Last. Kiyonori Yamaoka (RMIT: RMIT University)H-Index: 28
view all 9 authors...
: Although radon inhalation increases superoxide dismutase (SOD) activities in mouse organs, the mechanisms and pathways have not yet been fully clarified. The aim of this study was to determine the details of SOD activation in mouse brain tissue following the inhalation of radon at concentrations of 500 or 2000 Bq/m3 for 24 h. After inhalation, brains were removed quickly for analysis. Radon inhalation increased the manganese (Mn)-SOD level and mitochondrial SOD activity. However, the differenc...
Source
#1Uwe LangeH-Index: 26
#2Gabriel DischereitH-Index: 8
Last. Bernhard KürtenH-Index: 4
view all 7 authors...
Secondary osteoporosis is a frequent complication of rheumatoid arthritis (RA) and the result of an imbalance of catabolic and anabolic mechanisms of bone metabolism. The effects of serial low-dose radon and hyperthermia (LDRnHT) exposure in a therapeutic adit (12 applications in 3 weeks) on the serum levels of the cytokines osteoprotegerin (OPG), receptor activator of NF kappa-B ligand (RANKL), tumor necrosis factor-α (TNF-α), and also on the RANKL/OPG ratio were investigated in 25 RA patients ...
Source
Low-dose irradiation induces various stimulating effects, especially activation of the biological defense system including antioxidative and immune functions. Oxidative stress induced by reactive oxygen species (ROS) can cause cell damage and death and can induce many types of diseases. This paper reviews new insights into inhibition of ROS-related diseases with low-dose irradiation or radon inhalation. X-irradiation (0.5 Gy) before or after carbon tetrachloride (CCl4) treatment inhibits hepatop...
Source
#1Angelika ModerH-Index: 8
#2Heidi DobiasH-Index: 1
Last. Markus RitterH-Index: 35
view all 3 authors...
© 2013 Ritter et al., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Effects of Low-Dose Radon Therapy Applied Under Hyperthermic Conditions (RnHT) on Inflammatory and Non-Inflammatory Degenerative Disease Conditions
Source
Cited By0
Newest
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.