OX40L blockade cellular nanovesicles for autoimmune diseases therapy
Abstract
Current clinical agents for autoimmunity disorders treatment often cause substantial adverse effects and safety concerns, owing to non-specific immune modulation. Due to the prominent contribution of effector T cells in pathogenesis of rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), and preferential location of co-stimulatory receptor-ligand pair OX40-OX40L at the inflamed sites, selectively targeting autoaggressive T cells by...
Paper Details
Title
OX40L blockade cellular nanovesicles for autoimmune diseases therapy
Published Date
Sep 1, 2021
Volume
337
Pages
557 - 570
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