Controlled Release of Tetracycline Hydrochloride Loaded Highly Absorbent Alginate Submicron Fibers from Centrifugally Spinning

Highly absorbent alginate/polyethylene oxide submicron fibers containing the hydrophilic model drug tetracycline hydrochloride were prepared through centrifugal spinning. Pre-treatment with ethanol before crosslinking with calcium chloride solution maintained the structure of submicron fibers. The crosslinked submicron fibers could absorb phosphate buffer over 8 hours continuously, and they absorbed more phosphate buffer than commercial alginate...