ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection
Abstract
The shieldin complex functions as the downstream effector of 53BP1-RIF1 to promote DNA double-strand break end-joining by restricting end resection. The SHLD2 subunit binds to single-stranded DNA ends and blocks end resection through OB-fold domains. Besides blocking end resection, it is unclear how the shieldin complex processes SHLD2-bound single-stranded DNA and promotes non-homologous end-joining. Here, we identify a downstream effector of...
Paper Details
Title
ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection
Published Date
Aug 1, 2021
Journal
Volume
23
Issue
8
Pages
894 - 904
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