KUS121 attenuates the progression of monosodium iodoacetate-induced osteoarthritis in rats
Abstract
Currently there is no effective treatment available for osteoarthritis (OA). We have recently developed Kyoto University Substances (KUSs), ATPase inhibitors specific for valosin-containing protein (VCP), as a novel class of medicine for cellular protection. KUSs suppressed intracellular ATP depletion, endoplasmic reticulum (ER) stress, and cell death. In this study, we investigated the effects of KUS121 on chondrocyte cell death. In cultured...
Paper Details
Title
KUS121 attenuates the progression of monosodium iodoacetate-induced osteoarthritis in rats
Published Date
Aug 2, 2021
Journal
Volume
11
Issue
1
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