Tumor-derived LIF promotes chemoresistance via activating tumor-associated macrophages in gastric cancers
Abstract
Chemotherapy is the preferred clinical treatment for advanced stage gastric cancer (GC) patients, of which efficacy could be markedly impaired due to the development of chemoresistance. Alternatively activated or M2-type tumor associated macrophages (TAMs) are recruited under chemotherapy and are highly implicated in the chemoresistance development, but underlying molecular mechanism for TAM activation is largely unknown. Here, we present that...
Paper Details
Title
Tumor-derived LIF promotes chemoresistance via activating tumor-associated macrophages in gastric cancers
Published Date
Sep 1, 2021
Journal
Volume
406
Issue
1
Pages
112734 - 112734
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