Importance of HLA in Determining Individual Differences in the Onset of Adverse Drug Reactions
Abstract
Individuals vary in their susceptibility to adverse reactions to medications, some of which can be potentially life-threatening. Idiosyncratic drug toxicity (IDT) has been shown to be strongly associated to specific polymorphisms in genes encoding human leukocyte antigens (HLAs) by recent genome-wide association studies. However, the pathogenic mechanisms governing such reactions remain unclarified, at least in part because of a lack of suitable...
Paper Details
Title
Importance of HLA in Determining Individual Differences in the Onset of Adverse Drug Reactions
Published Date
Aug 1, 2021
Journal
Volume
141
Issue
8
Pages
1001 - 1007
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