A PSMA-targeted bispecific antibody for prostate cancer driven by a small-molecule targeting ligand
Abstract
Despite the development of next-generation antiandrogens, metastatic castration-resistant prostate cancer (mCRPC) remains incurable. Here, we describe a unique semisynthetic bispecific antibody that uses site-specific unnatural amino acid conjugation to combine the potency of a T cell-recruiting anti-CD3 antibody with the specificity of an imaging ligand (DUPA) for prostate-specific membrane antigen. This format enabled optimization of structure...
Paper Details
Title
A PSMA-targeted bispecific antibody for prostate cancer driven by a small-molecule targeting ligand
Published Date
Aug 13, 2021
Journal
Volume
7
Issue
33
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