Mendelian randomization under the omnigenic architecture.

Volume: 22, Issue: 6
Published: Nov 5, 2021
Abstract
Mendelian randomization (MR) is a common analytic tool for exploring the causal relationship among complex traits. Existing MR methods require selecting a small set of single nucleotide polymorphisms (SNPs) to serve as instrument variables. However, selecting a small set of SNPs may not be ideal, as most complex traits have a polygenic or omnigenic architecture and are each influenced by thousands of SNPs. Here, motivated by the recent omnigenic...
Paper Details
Title
Mendelian randomization under the omnigenic architecture.
Published Date
Nov 5, 2021
Volume
22
Issue
6
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