Reduced pannexin 1–IL-33 axis function in donor livers increases risk of MRSA infection in liver transplant recipients
Abstract
Liver transplantation patients are at increased risk for methicillin-resistant Staphylococcus aureus (MRSA) infection, but the molecular mechanism remains unclear. We found that genetic predisposition to low pannexin 1 (PANX1) expression in donor livers was associated with MRSA infection in human liver transplantation recipients. Using Panx1 and Il-33-knockout mice for liver transplantation models with MRSA tail vein injection, we demonstrated...
Paper Details
Title
Reduced pannexin 1–IL-33 axis function in donor livers increases risk of MRSA infection in liver transplant recipients
Published Date
Aug 11, 2021
Volume
13
Issue
606
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