Synthetic gene circuits as tools for drug discovery
Abstract
Within mammalian systems, there exists enormous opportunity to use synthetic gene circuits to enhance phenotype-based drug discovery, to map the molecular origins of disease, and to validate therapeutics in complex cellular systems. While drug discovery has relied on marker staining and high-content imaging in cell-based assays, synthetic gene circuits expand the potential for precision and speed. Here we present a vision of how circuits can...
Paper Details
Title
Synthetic gene circuits as tools for drug discovery
Published Date
Feb 1, 2022
Journal
Volume
40
Issue
2
Pages
210 - 225
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