miR-378-3p Knockdown Recapitulates Many of the Features of Myelodysplastic Syndromes
Abstract
Myelodysplastic syndromes (MDS) are clonal neoplasms of the hematopoietic stem cell that result in aberrant differentiation of hematopoietic lineages caused by a wide range of underlying genetic, epigenetic, and other causes. Despite the myriad origins, a recognizable MDS phenotype has been associated with miRNA aberrant expression. A model of aberrant myeloid maturation that mimics MDS was generated using a stable knockdown of miR-378-3p. This...
Paper Details
Title
miR-378-3p Knockdown Recapitulates Many of the Features of Myelodysplastic Syndromes
Published Date
Nov 1, 2021
Volume
191
Issue
11
Pages
2009 - 2022
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