Spontaneous and inherited TP53 genetic alterations

Volume: 40, Issue: 41, Pages: 5975 - 5983
Published: Aug 13, 2021
Abstract
The p53 protein is a transcription factor that prevents tumors from developing. In spontaneous and inherited cancers there are many different missense mutations in the DNA binding domain of the TP53 gene that contributes to tumor formation. These mutations produce a wide distribution in the transcriptional capabilities of the mutant p53 proteins with over four logs differences in the efficiencies of forming cancers in many diverse tissue types....
Paper Details
Title
Spontaneous and inherited TP53 genetic alterations
Published Date
Aug 13, 2021
Journal
Volume
40
Issue
41
Pages
5975 - 5983
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