Genetic and epigenetic orchestration of Gfi1aa-Lsd1-cebpα in zebrafish neutrophil development
Abstract
Neutrophils are the most abundant vertebrate leukocytes and they are essential to host defense. Despite extensive investigation, the molecular network controlling neutrophil differentiation remains incompletely understood. GFI1 is associated with several myeloid disorders, but its role and the role of its co-regulators in granulopoiesis and pathogenesis are far from clear. Here, we demonstrate that zebrafish gfi1aa deficiency induces excessive...
Paper Details
Title
Genetic and epigenetic orchestration of Gfi1aa-Lsd1-cebpα in zebrafish neutrophil development
Published Date
Aug 10, 2021
Journal
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History