Efficacy comparison of chlorhexidine and iodine preparation in reduction of surgical site infection: A systemic review and meta-analysis

Published on Aug 6, 2021in International Journal of Nursing Studies3.783
· DOI :10.1016/J.IJNURSTU.2021.104059
Li Li (HMU: Harbin Medical University), Yu Wang (HMU: Harbin Medical University), Shouyan Wang (HMU: Harbin Medical University)
Abstract null null Background null Chlorhexidine and povidone-iodine are the most common disinfectants used in preoperative skin preparation. However, there is no consistent conclusion regarding the prevention of surgical site infection (SSI) and bacterial culture data. null null null Objective null To assess the efficacy of chlorhexidine and povidone-iodine in the prevention of postoperative SSI and relevant bacterial data. null null null Design null Systematic Review and Meta-Analysis null null null Settings null N/A null null null Participants null N/A null null null Method null Literature relevant to “skin antisepsis” and “surgical site infections” was retrieved from PUBMED, Web of Science, EMBASE, CINHAL and CNKI. The incidence of SSI was the primary outcome, while the secondary outcome was bacterial data from the infected incision. All data were analyzed with Revman 5.3 and Stata Statistical Software. null null null Results null A total of 36 studies were identified in this study, which included 16,872 participants. This study revealed that chlorhexidine is superior to povidone-iodine in the prevention of postoperative SSI (risk ratio [RR], 0.73; 95% confidence interval [CI], 0.61–0.87; p = 0.019, I2 = 39%). Further meta-regression analysis revealed that the effect of chlorhexidine was directly associated with the type of incision, but failed to differentiate between the subgroups divided according to the type of incision. With respect to bacteria colonization, the most common bacteria for chlorhexidine arm were propionibacterium's, while the most common bacteria for the iodine arm were staphylococci species. null null null Conclusion null In comparison to povidone-iodine, chlorhexidine showed better results in preventing postoperative SSI.
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