Room-temperature Formal Aza-Wacker Cyclization through Synergistic Copper/TEMPO-catalyzed Radical Relay

A formal aza-Wacker cyclization through a synergistic Cu/TEMPO-catalyzed radical relay pathway, using N-fluorobenzenesulfonimide (NFSI) as an external oxidant, is reported. In this efficient cyclization of alkenylated carbamates or amides at room temperature, the imidyl nitrogen-centered radical (NCR) generated by NFSI induces carbamate or amido NCR from the substrate via N–H homolysis to realize the radical relay process, which was supported by...