Six-Month In Vivo Safety Profiling of Topical Ocular AAV5–Decorin Gene Transfer
Volume: 10, Issue: 10, Pages: 5 - 5
Published: Aug 12, 2021
Abstract
A significant remission of corneal fibrosis and neovascularization in rabbit eye in vivo was observed from a tissue-selective localized adeno-associated virus (AAV)5-Decorin (Dcn) gene therapy. This study sought to investigate 6-month toxicity profiling of this gene therapy for the eye in vivo using a rabbit model.A small epithelial scrape followed by corneal drying was performed unilaterally in 12 rabbit eyes and either AAV5-Dcn (n = 6) or...
Paper Details
Title
Six-Month In Vivo Safety Profiling of Topical Ocular AAV5–Decorin Gene Transfer
Published Date
Aug 12, 2021
Volume
10
Issue
10
Pages
5 - 5
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