Targeting TRK: A fast-tracked application of precision oncology and future directions

Volume: 165, Pages: 103451 - 103451
Published: Sep 1, 2021
Abstract
The NTRK genes encode the tropomyosin-related receptor tyrosine kinases TrkA, TrkB and TrkC. TRK receptors regulate the proliferation, differentiation, and survival of many neuronal and non-neuronal glial cells during embryogenesis, thus playing a critical role in synaptic plasticity and the development of nociceptive pathways. Recurrent genomic alterations in NTRK genes, typically fusions involving the 3′ region encoding the kinase domain...
Paper Details
Title
Targeting TRK: A fast-tracked application of precision oncology and future directions
Published Date
Sep 1, 2021
Volume
165
Pages
103451 - 103451
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