Identification of a EML4-ALK exon 19 fusion variant in lung adenocarcinoma and alectinib resistance
Abstract
Alectinib, a highly selective inhibitor of anaplastic lymphoma kinase (ALK), has shown a high response rate and long progression-free survival in primary treatment of ALK-positive non-small-cell lung cancer (NSCLC). De novo resistance or refractory subtype is rare event. Herein, we identify the first case with serial next-generation sequencing (NGS) results that harboured a rare echinoderm microtubule associated protein like 4 gene (EML4) -ALK...
Paper Details
Title
Identification of a EML4-ALK exon 19 fusion variant in lung adenocarcinoma and alectinib resistance
Published Date
Oct 1, 2021
Journal
Volume
160
Pages
32 - 35
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