Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation

Volume: 36, Issue: 5, Pages: 109487 - 109487
Published: Aug 1, 2021
Abstract
Ketone bodies are bioactive metabolites that function as energy substrates, signaling molecules, and regulators of histone modifications. β-hydroxybutyrate (β-OHB) is utilized in lysine β-hydroxybutyrylation (Kbhb) of histones, and associates with starvation-responsive genes, effectively coupling ketogenic metabolism with gene expression. The emerging diversity of the lysine acylation landscape prompted us to investigate the full proteomic...
Paper Details
Title
Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation
Published Date
Aug 1, 2021
Volume
36
Issue
5
Pages
109487 - 109487
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