Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer
Abstract
Inhibitors of apoptosis proteins (IAPs) are intracellular proteins, with important roles in regulating cell death, inflammation, and immunity. Here, we examined the clinical and therapeutic relevance of IAPs in colorectal cancer. We found that elevated expression of cIAP1 and cIAP2 (but not XIAP) significantly correlated with poor prognosis in patients with microsatellite stable (MSS) stage III colorectal cancer treated with 5-fluorouracil...
Paper Details
Title
Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer
Published Date
Aug 13, 2021
Volume
20
Issue
9
Pages
1627 - 1639
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