Pannexin biology and emerging linkages to cancer

Volume: 7, Issue: 12, Pages: 1119 - 1131
Published: Dec 1, 2021
Abstract
Pannexins are a family of glycoproteins that comprises three members, PANX1, PANX2, and PANX3. The widely expressed and interrogated PANX1 forms heptameric membrane channels that primarily serve to connect the cytoplasm to the extracellular milieu by being selectively permeable to small signaling molecules when activated. Apart from notable exceptions, PANX1 in many tumor cells appears to facilitate tumor growth and metastasis, suggesting that...
Paper Details
Title
Pannexin biology and emerging linkages to cancer
Published Date
Dec 1, 2021
Volume
7
Issue
12
Pages
1119 - 1131
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