Vitamins E and C do not effectively inhibit low density lipoprotein oxidation by ferritin at lysosomal pH
Abstract
Low density lipoprotein (LDL) might be oxidized by iron in the lysosomes of macrophages in atherosclerotic lesions. We have shown previously that the iron-storage proteinferritin can oxidize LDL at lysosomal pH. We have now investigated the roles of the most important antioxidant contained in LDL, α-tocopherol (the main form of vitamin E) and of ascorbate (vitamin C), a major water-soluble antioxidant, on LDL oxidation by ferritin at lysosomal...
Paper Details
Title
Vitamins E and C do not effectively inhibit low density lipoprotein oxidation by ferritin at lysosomal pH
Published Date
May 4, 2021
Journal
Volume
55
Issue
5
Pages
525 - 534
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History