Pirfenidone in heart failure with preserved ejection fraction: a randomized phase 2 trial
Abstract
In heart failure with preserved ejection fraction (HFpEF), the occurrence of myocardial fibrosis is associated with adverse outcome. Whether pirfenidone, an oral antifibrotic agent without hemodynamic effect, is efficacious and safe for the treatment of HFpEF is unknown. In this double-blind, phase 2 trial ( NCT02932566 ), we enrolled patients with heart failure, an ejection fraction of 45% or higher and elevated levels of natriuretic peptides....
Paper Details
Title
Pirfenidone in heart failure with preserved ejection fraction: a randomized phase 2 trial
Published Date
Aug 1, 2021
Journal
Volume
27
Issue
8
Pages
1477 - 1482
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