Detection of single amino acid differences in haemoglobin from blood samples using a nanopore

Published: Jul 9, 2021
Abstract
The real-time identification of protein biomarkers is under intense investigation for the development of point-of-care and portable devices. Here we use a PlyAB biological nanopore to detect a range of folded Haemoglobin (Hb) variants in blood samples. Blockades of HbA and sickle cell anaemia HbS, which differ by just one amino acid, and fetal HbF were distinguished with more than 97% accuracy on the basis of individual events. This nanopore...
Paper Details
Title
Detection of single amino acid differences in haemoglobin from blood samples using a nanopore
Published Date
Jul 9, 2021
Journal
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