Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation
Abstract
Allergic airway inflammation is driven by type-2 CD4+ T cell inflammatory responses. We uncover an immunoregulatory role for the nucleotide release channel, Panx1, in T cell crosstalk during airway disease. Inverse correlations between Panx1 and asthmatics and our mouse models revealed the necessity, specificity, and sufficiency of Panx1 in T cells to restrict inflammation. Global Panx1−/− mice experienced exacerbated airway inflammation, and...
Paper Details
Title
Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation
Published Date
Aug 1, 2021
Journal
Volume
54
Issue
8
Pages
1715 - 1727.e7
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