Macrophage depletion increases target specificity of bone‐targeted nanoparticles

Despite efforts to achieve tissue selectivity, the majority of systemically administered drug delivery systems (DDSs) are cleared by the mononuclear phagocyte system (MPS) before reaching target tissues regardless of disease or injury pathology. Previously, we showed that while tartrate‐resistant acid phosphatase (TRAP) binding peptide (TBP)‐targeted polymeric nanoparticles (TBP‐NP) delivering a bone regenerative Wnt agonist improved NP fracture...