PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity
Abstract
PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto substrates to change their function. Here, we identify PARP7 as a negative regulator of nucleic acid sensing in tumor cells. Inhibition of PARP7 restores type I interferon (IFN) signaling responses to nucleic acids in tumor models. Restored signaling can directly inhibit cell proliferation and activate the immune system, both of which contribute to tumor...
Paper Details
Title
PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity
Published Date
Sep 1, 2021
Journal
Volume
39
Issue
9
Pages
1214 - 1226.e10
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