Molecular foundations of prion strain diversity

Volume: 72, Pages: 22 - 31
Published: Feb 1, 2022
Abstract
Despite being caused by a single protein, prion diseases are strikingly heterogenous. Individual prion variants, known as strains, possess distinct biochemical properties, form aggregates with characteristic morphologies and preferentially seed certain brain regions, causing markedly different disease phenotypes. Strain diversity is determined by protein structure, post-translational modifications and the presence of extracellular matrix...
Paper Details
Title
Molecular foundations of prion strain diversity
Published Date
Feb 1, 2022
Volume
72
Pages
22 - 31
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