Reactive oxide species-scavenging lipid-polymer nanoparticles for neuroprotection after spinal cord injury

• A ROS responsive polymer, poly(PMT-co-EGDM), was synthesized and used to construct ROS-scavenging lipid-polymer nanoparticles (PELPNPs). • PELPNPs exhibited a good ROS-scavenging ability both in vitro and in vivo . • PELPNPs could reduce the ROS-induced inflammation and protect neurons against oxidative damages. • PELPNPs reduced the secondary injury and promoted functional recovery in a rat contusion injury model. Suppression of secondary...