Rescuing kidney patients from early demise: role of anti-cytokine therapies

Biomarkers of the inflammatory state are elevated in individuals with chronic kidney disease (CKD) and are also robust predictors of cardiovascular disease (CVD) and mortality in this population. In addition to its predictive ability, inflammation has been implicated in the pathogenesis of atherosclerotic CVD, primarily through NLRP3 inflammasome and interleukin-1 (IL-1) and interleukin-6 (IL-6) signaling pathways. 1 Tinti F. Lai S. Noce A. et...