INR and COVID-19 severity and mortality: A systematic review with meta-analysis and meta-regression

D-dimer elevations, suggesting a pro-thrombotic state and coagulopathy, predict adverse outcomes in coronavirus disease 2019 (COVID-19). However, the clinical significance of other coagulation markers, particularly the international normalized ratio (INR), is not well established. We conducted a systematic review and meta-analysis of the INR in COVID-19.A literature search was conducted in PubMed, Web of Science and Scopus, between January 2020...