Clinical Genetic Risk Variants Inform a Functional Protein Interaction Network for Tetralogy of Fallot

Volume: 14, Issue: 4
Published: Aug 1, 2021
Abstract
Background: Tetralogy of Fallot (TOF)—the most common cyanotic heart defect in newborns—has evidence of multiple genetic contributing factors. Identifying variants that are clinically relevant is essential to understand patient-specific disease susceptibility and outcomes and could contribute to delineating pathomechanisms. Methods: Using a clinically driven strategy, we reanalyzed exome sequencing data from 811 probands with TOF, to identify...
Paper Details
Title
Clinical Genetic Risk Variants Inform a Functional Protein Interaction Network for Tetralogy of Fallot
Published Date
Aug 1, 2021
Journal
Volume
14
Issue
4
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