B-PO05-143 CLINICAL OUTCOMES OF INAPPROPRIATE DOSING OF DIRECT ORAL ANTICOAGULANTS IN ATRIAL FIBRILLATION: A META-ANALYSIS

Direct Oral Anticoagulants (DOACs) are frequently dosed inappropriately, but the clinical impact of inappropriate dosing needs clearer characterization. We aimed to examine the association between inappropriate (off-label) DOAC dosing and clinical outcomes among atrial fibrillation patients. We performed a systematic search of PubMed, Ovid, and Embase from Jan 1, 2010, to Dec 31, 2020. Paired reviewers independently extracted data. The primary...