Evolving biological associations of upfront cytoreductive nephrectomy in metastatic renal cell carcinoma

Systemic responses to cytoreductive nephrectomy (CN) in the management of metastatic renal cell carcinoma (mRCC) are variable and difficult to anticipate. The authors aimed to determine the association of CN with modifiable International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk factors and oncological outcomes.Consecutive patients with mRCC referred for potential CN (2009-2019) were reviewed. The primary outcome was...