PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis

Volume: 102, Pages: 70 - 84
Published: Aug 1, 2021
Abstract
The formation of elastic fibers is active only in the perinatal period. How elastogenesis is developmentally regulated is not fully understood. Citrullination is a unique form of post-translational modification catalyzed by peptidylarginine deiminases (PADs), including PAD1-4. Its physiological role is largely unknown. By using an unbiased proteomic approach of lung tissues, we discovered that FBLN5 and LTBP4, two key elastogenic proteins, were...
Paper Details
Title
PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis
Published Date
Aug 1, 2021
Volume
102
Pages
70 - 84
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