BRCA mutations in pancreatic cancer and progress in their targeting

Volume: 25, Issue: 7, Pages: 547 - 557
Published: Jul 3, 2021
Abstract
Introduction: Genomic instability resulting from DNA damage repair (DDR) deficiencies is a hallmark of cancer and offers treatment opportunities. Homologous recombination DDR defect is a result of multiple critical gene mutations, including BRCA1/2. Targeting DNA DDR defects in pancreatic cancer (PC) is emerging as a potential treatment strategy with current focus on BRCA mutations.Areas covered: Challenges in treating patients with PC are...
Paper Details
Title
BRCA mutations in pancreatic cancer and progress in their targeting
DOI
Published Date
Jul 3, 2021
Journal
Volume
25
Issue
7
Pages
547 - 557
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