In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host
Abstract
Zoonotic transfer of animal pathogens to human hosts can generate novel agents, but the genetic events following such host jumps are not well studied. Here we characterize the mechanisms driving adaptive evolution of the emerging zoonotic pathogen Bordetella hinzii in a patient with interleukin-12 receptor β1 deficiency. Genomic sequencing of 24 B. hinzii isolates cultured from blood and stool over 45 months revealed a clonal lineage that had...
Paper Details
Title
In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host
Published Date
Jul 23, 2021
Journal
Volume
12
Issue
1
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