Inhibition of an organophosphate-detoxifying bacterial phosphotriesterase by albumin and plasma thiol components
Abstract
The phosphotriesterase of the bacterium Brevundimonas diminuta (BdPTE) is a naturally occurring enzyme that catalyzes the hydrolysis of organophosphate (OP) nerve agents as well as pesticides and offers a potential treatment of corresponding intoxications. While BdPTE mutants with improved catalytic efficiencies against several OPs have been described, unexpectedly, less efficient breakdown of an OP was observed upon application in an animal...
Paper Details
Title
Inhibition of an organophosphate-detoxifying bacterial phosphotriesterase by albumin and plasma thiol components
Published Date
Oct 1, 2021
Journal
Volume
350
Pages
194 - 201
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