Proline Synthesis Through PYCR1 is Required to Support Cancer Cell Proliferation and Survival in Oxygen-Limiting Conditions

The demands of cancer cell proliferation alongside an inadequate angiogenic response leads to insufficient oxygen availability in the tumour microenvironment. Within the mitochondria, oxygen is the major electron acceptor for NADH, with the result that the reducing activity of the tricarboxylic acid (TCA) cycle and mitochondrial respiration are functionally linked. As the oxidising activity of the TCA cycle is required for efficient synthesis of...