B-PO03-028 BIPOLAR PULSED ELECTRIC FIELD ABLATION OF THE INTERVENTRICULAR SEPTUM

Ablation of deep septal substrate with thermal energy sources conveys many challenges including inadequate lesion depth, inadvertent steam pops, and conduction system injury. Pulsed electric fields (PEF) were delivered across the interventricular septum as a preclinical proof-of-concept for transmural ablation through irreversible electroporation. In 8 healthy canine 4-week survival experiments, microsecond (n=2; 75-189J/animal) or nanosecond...