Carbopol-olive oil-based bigel drug delivery system of doxycycline hyclate for the treatment of acne

The objective of this study was to prepare and evaluate the doxycycline hyclate containing bigel for the effective treatment of acne.Bigels are biphasic systems formed by water-based hydrogels and oil-based organogel. Carbopol 940 was used to prepare the hydrogel phase, whereas Span-60 and olive oil for the oleogel phase.The microstructure of bigel confirmed the oil in water type emulsion formation. The average droplet size of formulations was...